St. George's was founded in 1767, meeting initially in a sail loft on Dock Street, and in 1769 it purchased the shell of a building which had been erected in 1763 by a German Reformed congregation. At this time, Methodists had not yet broken away from the Anglican Church and the Methodist Episcopal Church was not founded until 1784. In the 1920s, a court case saved the church from being demolished to make way for the Benjamin Franklin Bridge. The case resulted in the bridge being relocated. The church also includes a museum.